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At 28 weeks of pregnancy —A small number of Rhnegative women may be exposed to Rhpositive blood cells from the fetus in the last few months of pregnancy and may make antibodies against these cells RhIg given at 28 weeks of pregnancy destroysApr 08, 11 · Rh incompatibility occurs when a pregnant woman whose blood type is Rhnegative is exposed to Rhpositive blood from her fetus, leading to the mother's development of Rh antibodiesThese antibodies have the potential to cross the placenta and attach to fetal red blood cells, resulting in hemolysis, or destruction of the fetus's red blood cells This causes theAlloimmunization, often called Rhisoimmunization or Rh incompatibility was first described in Rh negative women with an Rhpositive fetus, but it can occur with many other blood type incompatibilities It is a condition that may occur during pregnancy when there is an incompatibility between your blood type and your baby's blood type Management Of The Rhesus Negative Mother